|
rs967461896
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One eccrine gland adenocarcinoma showed allelic loss of 17p and a Cys 176 Arg mutation in the p53 gene.
|
10660129 |
2000 |
|
rs9370729
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Pooled evaluation of cases from the two aforementioned studies suggested differences in the distribution of susceptibility alleles by histology; adenocarcinoma cases were more likely to be carriers of the susceptibility alleles for SNP rs9370729 (p-trend=0.02) and SNP rs750749 (p-trend=0.09).
|
19446866 |
2009 |
|
rs909253
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the subgroup analysis, significant association of rs909253 was found in adenocarcinoma (OR = 1.16, P (z) < 0.001) and hematological malignancy (OR = 1.10, P (z) < 0.001).
|
24136744 |
2014 |
|
rs876658657
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no significant association between the hMLH1 -93G-->A genotype and the risk for adenocarcinoma or small cell carcinoma.
|
15382050 |
2004 |
|
rs863225307
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both tumor phenotypes resulted characterized by a p.E542K point mutation in the PIK3CA gene, whereas adenocarcinoma component revealed also a TP53 Q331* homozygous stop mutation.
|
28698100 |
2017 |
|
rs833061
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, when the patients were stratified by tumor histology, squamous cell carcinoma (SCC) and adenocarcinoma (AC) had significantly different OS (Adjusted hazard ratio [aHR] = 0.76, 95% CI = 0.56-1.03 in SCC; aHR = 1.33, 95% CI = 0.98-1.82 in AC; P for heterogeneity = 0.01) and DFS (aHR = 0.75, 95% CI = 0.58-0.97 in SCC; aHR = 1.26, 95% CI = 1.00-1.60 in AC; P for heterogeneity = 0.004) according to the rs833061T>C genotypes.
|
27709850 |
2016 |
|
rs8305
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An SNP, Thr706Ala, in the POLI gene encoding another translesion DNA polymerase was associated with adenocarcinoma and squamous cell carcinoma risk, particularly in individuals of ages < 61 years (OR Ala/Ala + Ala/Thr vs. Thr/Thr = 1.5 and 2.4, respectively).
|
15609317 |
2005 |
|
rs8038415
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, evaluating selected IGF1R SNPs, patients with adenocarcinomas and homozygous for the rs8038415 T-allele had a significantly better survival (P = .025) but no different disease-free survival.
|
24745618 |
2014 |
|
rs79184941
|
|
|
0.010 |
GeneticVariation |
BEFREE |
All 3 mutations were S252W and occurred in endometrioid (type I) adenocarcinomas.
|
21285871 |
2011 |
|
rs782212015
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found mutations encoding L640I and A643T in the B3 domain of human CEACAM5 in colorectal adenocarcinomas; structural studies indicated that these mutations would alter the interaction between CEACAM5 and TGFBR1.
|
31585122 |
2020 |
|
rs779577244
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, an adenocarcinoma patient harboring concurrent <i>RET</i> fusion and <i>EGFR</i> L858R responded to combinatorial treatment of cabozantinib and osimertinib, with a progression-free survival of 5 months.
|
30131091 |
2019 |
|
rs778826879
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Atypical adenomatous hyperplasia and small adenomas were observed in CCSP-rtTA/tetO-SHP2(E76K) bitransgenic mice induced with Dox for 2-6 months and progressed to larger adenoma and adenocarcinoma by 9 months.
|
24480804 |
2014 |
|
rs767808984
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These data demonstrate that NKX2-1 functions in a context-dependent manner in lung tumorigenesis and inhibits Kras(G12D)-driven mucinous pulmonary adenocarcinoma.
|
23143308 |
2012 |
|
rs766779326
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of three heterozygous missense ESR1 mutations, p.K303R (c.908A>G), p.T311M (c.932C>T) and p.Y537C (c.1610A>G), were identified in 3/207 (1.4%) cervical squamous cell carcinoma samples, which were absent in 27 adenosquamous carcinomas and 26 adenocarcinomas samples.
|
31452755 |
2019 |
|
rs765660823
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Q808H variation in the DDR2 gene was detected in one SCC sample, while no variant was seen in the ADC and LCC subtypes.
|
30048458 |
2018 |
|
rs764664272
|
|
|
0.010 |
GeneticVariation |
BEFREE |
K-rasLSL-G12D mice were imaged serially during the development of adenocarcinomas using fluorescence molecular tomography (FMT) and a probe specific for MMP-2, -3, -9 and -13.
|
26193700 |
2015 |
|
rs762846821
|
|
|
0.080 |
GeneticVariation |
BEFREE |
TVA-mediated infection of genetically engineered mice with endogenous expression of Kras(G12D) in pancreatic progenitor cells by using RCASBP(A) virus carrying a short hairpin RNA directed against murine TP53, resulted in dramatically enhanced progression to invasive adenocarcinomas.
|
18621715 |
2008 |
|
rs762846821
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We show here that concomitant expression of Kras(G12D) and haploinsufficiency of the Smad4/Dpc4 tumor suppressor gene engenders a distinct class of pancreatic tumors, mucinous cystic neoplasms (MCNs), which culminate in invasive ductal adenocarcinomas.
|
17349581 |
2007 |
|
rs762846821
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Using genetically engineered mouse models, we show that heterozygous mutation of Dpc4/Smad4 attenuates the metastatic potential of Kras(G12D/+);Trp53(R172H/+) pancreatic ductal adenocarcinomas while increasing their proliferation.
|
26004068 |
2015 |
|
rs762846821
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Mice with pancreas-specific tsTAg expression developed acinar cell dysplasia by 22 weeks without PanIN formation, while mice expressing both tsTAg and Kras(G12D) developed highly aggressive adenocarcinoma with a ductal cell phenotype within a short period, and died within 3 weeks.
|
25042889 |
2014 |
|
rs762846821
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Loss of Pten in the Kras(G12D);Amhr2-Cre mutant mice leads to the transformation of ovarian surface epithelial (OSE) cells and rapid development of low-grade, invasive serous adenocarcinomas.
|
22396451 |
2012 |
|
rs762846821
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Firstly, lentivirus-mediated transduction of KRAS(G12V), MYC and human papillomavirus 16 (HPV16) E6/E7 under the control of a tetracyclin-inducible promoter efficiently immortalized and transformed primary HPDECs, which gave rise to adenocarcinomas subcutaneously in an immune-deficient mouse xenograft model, depending on expression of the four genes.
|
24858378 |
2014 |
|
rs762846821
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Transcriptional profiling of Kras(G12V)-driven mouse hyperplasias revealed intertumor diversity with a subset that exhibited an aggressive transcriptional profile analogous to that of advanced human adenocarcinomas.
|
26855149 |
2016 |
|
rs762846821
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The effect of NO-aspirin on pancreatic carcinogenesis was investigated by assessing the development of precursor pancreatic lesions and adenocarcinomas in Kras(G12D/+) transgenic mice that recapitulate human pancreatic cancer progression.
|
23019409 |
2012 |
|
rs759435862
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Plasma DNA samples from 73 patients with stage IIIB to IV adenocarcinoma were analyzed for EGFR mutations in exons 19 (deletion mutation) and 21 (L858R mutation) using direct DNA sequencing, DHPLC and Scorpions ARMS.
|
21518597 |
2011 |